- Hyperglycemia is a significant causative factor for the complications of diabetes mellitus, which results in significant morbidity and mortality for millions of Americans. Recent advances on the cellular effects of hyperglycemia places the overproduction of reactive oxygen species (ROS) by the mitochondrial electron transport chain as a strong candidate for the core abnormality that leads to other biochemical and cellular defects and the resulting tissue injury. The purpose of this RFA is to encourage the translation of these recent advances into therapies that can interrupt the increase in mitochondrial ROS and prevent their role in diabetic complications.
- R01 and R21 applications from qualified principal investigators are invited for basic or clinical studies for discovering and characterizing molecular targets, agents and assays related to the accumulation of mitochondrial ROS secondary to hyperglycemia.
- The participating institutes plan on contributing $2.5 million to fund 5-10 new awards with project periods of 2-4 years.
- Non-profit or for-profit organizations are eligible, including public or private institutions and domestic and foreign institutions.
- Applicants may submit more than one application, providing there is no scientific or budgetary overlap.
- The PHS 398 application can be obtained from http://grants.nih.gov/grants/funding/phs398/phs398.html
Who can apply:
City Or Township Governments
Federally Recognized Indian Tribal Governments
Independent School Districts
Native American Organization
Non-Government - General
Nonprofits Having A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Nonprofits That Do Not Have A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Other Private Institution/Organization
Private Institutions Of Higher Education
Private Nonprofit Institution/Organization (Includes Institutions Of Higher Education, Hospitals)
Public And State Controlled Institutions Of Higher Education
Public Housing Authorities/Indian Housing Authorities
Quasi-Public Nonprofit Institution/Organization
Small Business (Less Than 500 Employees
Special District Governments
State (Includes District Of Columbia; Includes Institutions Of Higher Education And Hospitals)
U.S. Territories And Possessions (Includes Institutions Of Higher Education, Hospitals)
Eligible functional categories:
Cancer Biology Research
Cancer Cause and Prevention Research
Diabetes, Endocrinology and Metabolism Research
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